<?xml version="1.0" encoding="UTF-8"?><mets:mets xmlns:mads="http://www.loc.gov/mads/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:tef="http://www.abes.fr/abes/documents/tef" xmlns:metsRights="http://cosimo.stanford.edu/sdr/metsrights/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mets="http://www.loc.gov/METS/">
    <mets:metsHdr ID="rennes1-ori-wf-1-9422" CREATEDATE="2017-04-05T15:53:50" LASTMODDATE="2017-04-05T15:53:53">
  <mets:agent ROLE="CREATOR">
            <mets:name>Université de Rennes 1</mets:name>
        </mets:agent>
</mets:metsHdr>
    <mets:dmdSec ID="desc_expr" CREATED="2017-04-05T15:53:50">
  <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_desc_these">
            <mets:xmlData>
                <tef:thesisRecord>
     <dc:title xml:lang="fr">Foie du sujet âgé: une physiologie spécifique? Conséquences pratiques afin d'adapter les soins</dc:title>
     <dcterms:alternative xml:lang="en">Is there a specific physiology of the liver of the elderly? Practical consequences to care adaptation</dcterms:alternative>
     <dc:subject xml:lang="fr">Foie</dc:subject><dc:subject xml:lang="fr">hépatocyte</dc:subject><dc:subject xml:lang="fr">stress oxydant</dc:subject><dc:subject xml:lang="fr">personne âgée</dc:subject><dc:subject xml:lang="fr">médicament</dc:subject><dc:subject xml:lang="fr">physiologie</dc:subject><dc:subject xml:lang="fr">pathologie</dc:subject>
     <dc:subject xml:lang="en">Liver</dc:subject><dc:subject xml:lang="en">hepatocyte</dc:subject><dc:subject xml:lang="en">oxidative stress</dc:subject><dc:subject xml:lang="en">elderly</dc:subject><dc:subject xml:lang="en">drug</dc:subject><dc:subject xml:lang="en">physiology</dc:subject><dc:subject xml:lang="en">pathology</dc:subject>
     <tef:sujetRameau><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="027256553">Foie‎--Maladies </tef:elementdEntree>
      <tef:subdivision autoriteSource="Sudoc" type="subdivisionDeSujet" autoriteExterne="167193996">Chez la personne âgée</tef:subdivision>
      <tef:subdivision autoriteSource="Sudoc" type="subdivisionDeForme" autoriteExterne="027253139">Thèses et écrits académiques</tef:subdivision>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="035005211">Stress oxydatif</tef:elementdEntree>
      <tef:subdivision autoriteSource="Sudoc" type="subdivisionDeForme" autoriteExterne="027253139">Thèses et écrits académiques</tef:subdivision>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="028675347">Foie‎--Effets des médicaments</tef:elementdEntree>
      <tef:subdivision autoriteSource="Sudoc" type="subdivisionDeForme" autoriteExterne="027253139">Thèses et écrits académiques</tef:subdivision>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="031057942">Produits chimiques‎--Effets physiologiques</tef:elementdEntree>
      <tef:subdivision autoriteSource="Sudoc" type="subdivisionDeForme" autoriteExterne="027253139">Thèses et écrits académiques</tef:subdivision>
					</tef:vedetteRameauNomCommun></tef:sujetRameau>
     
     
     
     <dcterms:abstract xml:lang="fr">Le foie du sujet âgé possède une physiologie bien spécifique avec des modifications anatomo-pathologiques, biochimiques et pharmacologiques qui ont des conséquences chez le patient âgé polymédicamenté. Les causes du vieillissement du foie sont multiples : immunitaire, hormonal et lié au stress oxydant, cela peut avoir des conséquences sur l’apparition de certaines pathologies hépatiques.
</dcterms:abstract>
     <dcterms:abstract xml:lang="en">In the elderly, patient liver has a specific physiology due to anatomo-pathologic, biochemical and pharmacological modifications and it leads to several consequences, especially on poly-medicated patients. Multiple causes leads to liver aging: immune, hormonal or stress oxidative causes; this can lead to several consequences like development of hepatic diseases.</dcterms:abstract>
     <dc:type>Electronic Thesis or Dissertation</dc:type><dc:type xsi:type="dcterms:DCMIType">Text</dc:type>
     <dc:language xsi:type="dcterms:RFC3066">fr</dc:language>
    </tef:thesisRecord>
            </mets:xmlData>
        </mets:mdWrap>
</mets:dmdSec>
    <mets:dmdSec ID="desc_edition" CREATED="2017-04-05T15:53:50">
  <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_desc_edition">
            <mets:xmlData>
                <tef:edition><dcterms:medium xsi:type="dcterms:IMT">application/pdf</dcterms:medium><dcterms:extent>1 : 2682 Ko</dcterms:extent><dc:identifier xsi:type="dcterms:URI">https://ecm.univ-rennes1.fr/nuxeo/site/esupversions/a972f232-f7eb-435d-908b-45edab17edbd</dc:identifier></tef:edition>
            </mets:xmlData>
        </mets:mdWrap>
</mets:dmdSec>
    <mets:amdSec>
        <mets:techMD ID="admin_expr" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_admin_these">
                <mets:xmlData>
                    <tef:thesisAdmin>
                        <tef:auteur>
       <tef:nom>Mousset</tef:nom>
       <tef:prenom>Marie</tef:prenom>
       
       <tef:dateNaissance>1987-12-21</tef:dateNaissance>
       <tef:nationalite scheme="ISO-3166-1">FR</tef:nationalite>
       <tef:autoriteExterne autoriteSource="Sudoc">203029968</tef:autoriteExterne>
       <tef:autoriteExterne autoriteSource="mailPerso">mousset.marie@gmail.com</tef:autoriteExterne>
      </tef:auteur>
                        <dc:identifier xsi:type="tef:NNT">2017REN1P011</dc:identifier>
                        <dc:identifier xsi:type="tef:nationalThesisPID">http://www.theses.fr/2017REN1P011</dc:identifier>
                        <dcterms:dateAccepted xsi:type="dcterms:W3CDTF">2017-04-06</dcterms:dateAccepted>
                        <tef:thesis.degree>
                            <tef:thesis.degree.discipline xml:lang="fr">Pharmacie</tef:thesis.degree.discipline>
                            <tef:thesis.degree.grantor>
        <tef:nom>Universite de Rennes 1</tef:nom><tef:autoriteInterne>thesis.degree.grantor_1</tef:autoriteInterne>
        
        <tef:autoriteExterne autoriteSource="Sudoc">02778715X</tef:autoriteExterne>
       </tef:thesis.degree.grantor>
                            <tef:thesis.degree.level>Doctorat (thèse d'exercice)</tef:thesis.degree.level>
                        </tef:thesis.degree>
                        <tef:theseSurTravaux>non</tef:theseSurTravaux>
                        <tef:avisJury>oui</tef:avisJury><tef:directeurThese><tef:nom>Aninat</tef:nom><tef:prenom>Caroline</tef:prenom><tef:autoriteInterne>intervenant_1</tef:autoriteInterne><tef:autoriteExterne autoriteSource="Sudoc">074729012</tef:autoriteExterne></tef:directeurThese>
      
      
      
                        
                        <tef:partenaireRecherche type="autreType" autreType="ComuE">
       <tef:nom>Universite Bretagne Loire</tef:nom><tef:autoriteInterne>partenaireRecherche_1</tef:autoriteInterne>
       
       <tef:autoriteExterne autoriteSource="Sudoc">191639044</tef:autoriteExterne>
      </tef:partenaireRecherche>
                        <tef:oaiSetSpec>ddc:610</tef:oaiSetSpec>
                        
                        
                    <tef:MADSAuthority authorityID="intervenant_1" type="personal"><tef:personMADS><mads:namePart type="family">Aninat</mads:namePart><mads:namePart type="given">Caroline</mads:namePart></tef:personMADS></tef:MADSAuthority><tef:MADSAuthority authorityID="thesis.degree.grantor_1" type="corporate"><tef:personMADS><mads:namePart>Universite de Rennes 1</mads:namePart><mads:description>Sciences et technologie, medecine, pharmacie, odontologie, droit, economie, gestion, philosophie</mads:description></tef:personMADS></tef:MADSAuthority><tef:MADSAuthority authorityID="partenaireRecherche_1" type="corporate"><tef:personMADS><mads:namePart>Universite Bretagne Loire</mads:namePart><mads:description>
        
        
        
        Communaute des etablissements d enseignement superieur et de recherche (ComuE)
       
       
       
       </mads:description></tef:personMADS></tef:MADSAuthority></tef:thesisAdmin>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:techMD><mets:techMD ID="file_1"><mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_tech_fichier"><mets:xmlData><tef:meta_fichier>
     <tef:encodage>ASCII</tef:encodage>
     <tef:formatFichier>PDF</tef:formatFichier>
     
     
     
     <tef:taille>2746719</tef:taille>
    </tef:meta_fichier></mets:xmlData></mets:mdWrap></mets:techMD>
        
        <mets:rightsMD ID="dr_expr_thesard" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_auteur_these">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="true" DISPLAY="true" COPY="true" DUPLICATE="true" MODIFY="false" DELETE="false" PRINT="true"/>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
        <mets:rightsMD ID="dr_expr_univ" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_etablissement_these">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="true" DISPLAY="true" COPY="true" DUPLICATE="true" MODIFY="false" DELETE="false" PRINT="true"/>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
        <mets:rightsMD ID="dr_version" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_version">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="true" DISPLAY="true" COPY="true" DUPLICATE="true" MODIFY="false" DELETE="false" PRINT="true"/>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
    </mets:amdSec>
    <mets:fileSec>
  <mets:fileGrp ID="FGrID1" USE="archive"><mets:file ID="FID1" ADMID="file_1" MIMETYPE="application/pdf" USE="maitre"><mets:FLocat LOCTYPE="URL" xlink:href="https://ecm.univ-rennes1.fr/nuxeo/site/esupversions/a972f232-f7eb-435d-908b-45edab17edbd"/></mets:file></mets:fileGrp>
 </mets:fileSec>
    <mets:structMap TYPE="logical">
        <mets:div DMDID="desc_expr" ADMID="dr_expr_thesard dr_expr_univ admin_expr" TYPE="THESE" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-9422/oeuvre">
            <mets:div ADMID="dr_version" TYPE="VERSION_COMPLETE" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-9422/oeuvre/version">
                <mets:div DMDID="desc_edition" TYPE="EDITION" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-9422/oeuvre/version/edition">
                    <mets:fptr FILEID="FGrID1"/>
                </mets:div>
            </mets:div>
        </mets:div>
    </mets:structMap>
</mets:mets>