<?xml version="1.0" encoding="UTF-8"?><mets:mets xmlns:mads="http://www.loc.gov/mads/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:tef="http://www.abes.fr/abes/documents/tef" xmlns:metsRights="http://cosimo.stanford.edu/sdr/metsrights/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mets="http://www.loc.gov/METS/">
    <mets:metsHdr ID="rennes1-ori-wf-1-8170" CREATEDATE="2016-05-27T15:00:50" LASTMODDATE="2016-05-27T15:00:51">
  <mets:agent ROLE="CREATOR">
            <mets:name>Université de Rennes 1</mets:name>
        </mets:agent>
</mets:metsHdr>
    <mets:dmdSec ID="desc_expr" CREATED="2016-05-27T15:00:50">
  <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_desc_these">
            <mets:xmlData>
                <tef:thesisRecord>
     <dc:title xml:lang="fr">Les perspectives dans la prise en charge thérapeutique de l'alcoolo-dépendance</dc:title>
     <dcterms:alternative xml:lang="en">Prospects in the therapeutic management of alcoholism</dcterms:alternative>
     <dc:subject xml:lang="fr">Alcoolo-dépendance</dc:subject><dc:subject xml:lang="fr">Thérapie</dc:subject><dc:subject xml:lang="fr">Allopathie</dc:subject><dc:subject xml:lang="fr">Phytothérapie</dc:subject><dc:subject xml:lang="fr">Homéopathie</dc:subject><dc:subject xml:lang="fr">Psychosocial.</dc:subject>
     <dc:subject xml:lang="en">Alcoholism</dc:subject><dc:subject xml:lang="en">Therapy</dc:subject><dc:subject xml:lang="en">Allopathy</dc:subject><dc:subject xml:lang="en">Homeopathy</dc:subject><dc:subject xml:lang="en">Phytotherapy</dc:subject><dc:subject xml:lang="en">Psychosocial.</dc:subject><tef:sujetRameau><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="027650588">Alcoolisme </tef:elementdEntree><tef:subdivision autoriteSource="Sudoc" type="subdivisionDeSujet" autoriteExterne="027589838">Thérapeutique</tef:subdivision><tef:subdivision autoriteSource="Sudoc" type="subdivisionDeForme" autoriteExterne="027253139">Thèses et écrits académiques</tef:subdivision>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="027241661">Psychologie sociale</tef:elementdEntree><tef:subdivision autoriteSource="Sudoc" type="subdivisionDeForme" autoriteExterne="027253139">Thèses et écrits académiques</tef:subdivision>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="027655008">Médecines parallèles</tef:elementdEntree><tef:subdivision autoriteSource="Sudoc" type="subdivisionDeForme" autoriteExterne="027253139">Thèses et écrits académiques</tef:subdivision>
					</tef:vedetteRameauNomCommun></tef:sujetRameau>
     <dcterms:abstract xml:lang="fr">Le mésusage d’alcool est très répandu en France. Deux types de consommations sont distingués et interdépendants : alcoolisation aiguë et alcoolisation chronique. Elles peuvent toutes les deux conduire à l’alcoolo-dépendance. La prise en charge actuelle associe une intervention psychosociale adaptée au patient et des pharmacothérapies spécifiques : disulfirame, acamprosate, baclofène, naltrexone et nalméfène. Mais elle ne mène qu’à des résultats mitigés. L’ évolution des connaissances scientifiques et fondamentales de la pathologie permet d’élaborer de potentiels leviers d’action, notamment dans le domaine de la pharmacothérapie : topiramate,  zonisamide, gabapentine, oxybate de sodium, mémantine, ivermectine, etc. Aussi, la possibilité d’intégrer des options de phytothérapie ou d’homéopathie, et de recourir à des méthodes de personnalisation des traitements, pourrait enrichir l’arsenal thérapeutique disponible.</dcterms:abstract>
     <dcterms:abstract xml:lang="en">Alcohol misuse is very widespread in France. There are two interdependent types of alcoholisation : acute and chronic.. They both can lead to alcoholism. Actually, there are psychosocial cares, ajusted to the patient, and specific pharmacotherapies : disulfiram, acamprosate, baclofene, naltrexone and nalmefene. But they only have mixed results. The evolution of scientific and fondamental knowledges about the pathology lead to potential ways of treatment, especially in pharmacotherapy domain  : topiramate, zonisamide, gabapentin, sodium oxybate, memantine, ivermectin, etc. Also, there is the possibility of using phytotherapy and homeopathy, and individualization of treatment methodology. This could improve the arsenal of treatment methods available.</dcterms:abstract>
     <dc:type>Electronic Thesis or Dissertation</dc:type><dc:type xsi:type="dcterms:DCMIType">Text</dc:type>
     <dc:language xsi:type="dcterms:RFC3066">fr</dc:language>
    </tef:thesisRecord>
            </mets:xmlData>
        </mets:mdWrap>
</mets:dmdSec>
    <mets:dmdSec ID="desc_edition" CREATED="2016-05-27T15:00:50">
  <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_desc_edition">
            <mets:xmlData>
                <tef:edition><dcterms:medium xsi:type="dcterms:IMT">application/pdf</dcterms:medium><dcterms:extent>1 : 10139 Ko</dcterms:extent><dc:identifier xsi:type="dcterms:URI">https://ecm.univ-rennes1.fr/nuxeo/site/esupversions/7877d29e-101a-4b50-b1e9-adfb14cd2ac8</dc:identifier></tef:edition>
            </mets:xmlData>
        </mets:mdWrap>
</mets:dmdSec>
    <mets:amdSec>
        <mets:techMD ID="admin_expr" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_admin_these">
                <mets:xmlData>
                    <tef:thesisAdmin>
                        <tef:auteur>
       <tef:nom>Bellec</tef:nom>
       <tef:prenom>Leslie</tef:prenom>
       
       <tef:dateNaissance>1987-04-16</tef:dateNaissance>
       <tef:nationalite scheme="ISO-3166-1">FR</tef:nationalite>
       <tef:autoriteExterne autoriteSource="Sudoc">198294069</tef:autoriteExterne>
       <tef:autoriteExterne autoriteSource="mailPerso">leslie.bellec@wanadoo.fr</tef:autoriteExterne>
      </tef:auteur>
                        <dc:identifier xsi:type="tef:NNT">2016REN1P042</dc:identifier>
                        <dc:identifier xsi:type="tef:nationalThesisPID">http://www.theses.fr/2016REN1P042</dc:identifier>
                        <dcterms:dateAccepted xsi:type="dcterms:W3CDTF">2016-06-22</dcterms:dateAccepted>
                        <tef:thesis.degree>
                            <tef:thesis.degree.discipline xml:lang="fr">Pharmacie</tef:thesis.degree.discipline>
                            <tef:thesis.degree.grantor>
        <tef:nom>Universite de Rennes 1</tef:nom><tef:autoriteInterne>thesis.degree.grantor_1</tef:autoriteInterne>
        
        <tef:autoriteExterne autoriteSource="Sudoc">02778715X</tef:autoriteExterne>
       </tef:thesis.degree.grantor>
                            <tef:thesis.degree.level>Doctorat (thèse d'exercice)</tef:thesis.degree.level>
                        </tef:thesis.degree>
                        <tef:theseSurTravaux>non</tef:theseSurTravaux>
                        <tef:avisJury>oui</tef:avisJury><tef:directeurThese><tef:nom>Marie</tef:nom><tef:prenom>Nicolas</tef:prenom><tef:autoriteInterne>intervenant_1</tef:autoriteInterne><tef:autoriteExterne autoriteSource="Sudoc">146156099</tef:autoriteExterne></tef:directeurThese>
      
      
      
                        
                        <tef:partenaireRecherche type="autreType" autreType="ComuE">
       <tef:nom>Universite Bretagne Loire</tef:nom><tef:autoriteInterne>partenaireRecherche_1</tef:autoriteInterne>
       
       <tef:autoriteExterne autoriteSource="Sudoc">191639044</tef:autoriteExterne>
      </tef:partenaireRecherche>
                        <tef:oaiSetSpec>ddc:610</tef:oaiSetSpec>
                        
                        
                    <tef:MADSAuthority authorityID="intervenant_1" type="personal"><tef:personMADS><mads:namePart type="family">Marie</mads:namePart><mads:namePart type="given">Nicolas</mads:namePart></tef:personMADS></tef:MADSAuthority><tef:MADSAuthority authorityID="thesis.degree.grantor_1" type="corporate"><tef:personMADS><mads:namePart>Universite de Rennes 1</mads:namePart><mads:description>Sciences et technologie, medecine, pharmacie, odontologie, droit, economie, gestion, philosophie</mads:description></tef:personMADS></tef:MADSAuthority><tef:MADSAuthority authorityID="partenaireRecherche_1" type="corporate"><tef:personMADS><mads:namePart>Universite Bretagne Loire</mads:namePart><mads:description>
        
        
        
        Communaute des etablissements d enseignement superieur et de recherche (ComuE)
       
       
       
       </mads:description></tef:personMADS></tef:MADSAuthority></tef:thesisAdmin>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:techMD><mets:techMD ID="file_1"><mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_tech_fichier"><mets:xmlData><tef:meta_fichier>
     <tef:encodage>ASCII</tef:encodage>
     <tef:formatFichier>PDF</tef:formatFichier>
     
     
     
     <tef:taille>10382690</tef:taille>
    </tef:meta_fichier></mets:xmlData></mets:mdWrap></mets:techMD>
        
        <mets:rightsMD ID="dr_expr_thesard" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_auteur_these">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="true" DISPLAY="true" COPY="true" DUPLICATE="true" MODIFY="false" DELETE="false" PRINT="true"/>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
        <mets:rightsMD ID="dr_expr_univ" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_etablissement_these">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="true" DISPLAY="true" COPY="true" DUPLICATE="true" MODIFY="false" DELETE="false" PRINT="true"/>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
        <mets:rightsMD ID="dr_version" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_version">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="true" DISPLAY="true" COPY="true" DUPLICATE="true" MODIFY="false" DELETE="false" PRINT="true"/>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
    </mets:amdSec>
    <mets:fileSec>
  <mets:fileGrp ID="FGrID1" USE="archive"><mets:file ID="FID1" ADMID="file_1" MIMETYPE="application/pdf" USE="maitre"><mets:FLocat LOCTYPE="URL" xlink:href="https://ecm.univ-rennes1.fr/nuxeo/site/esupversions/7877d29e-101a-4b50-b1e9-adfb14cd2ac8"/></mets:file></mets:fileGrp>
 </mets:fileSec>
    <mets:structMap TYPE="logical">
        <mets:div DMDID="desc_expr" ADMID="dr_expr_thesard dr_expr_univ admin_expr" TYPE="THESE" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-8170/oeuvre">
            <mets:div ADMID="dr_version" TYPE="VERSION_COMPLETE" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-8170/oeuvre/version">
                <mets:div DMDID="desc_edition" TYPE="EDITION" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-8170/oeuvre/version/edition">
                    <mets:fptr FILEID="FGrID1"/>
                </mets:div>
            </mets:div>
        </mets:div>
    </mets:structMap>
</mets:mets>