<?xml version="1.0" encoding="UTF-8"?><mets:mets xmlns:mads="http://www.loc.gov/mads/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:tef="http://www.abes.fr/abes/documents/tef" xmlns:metsRights="http://cosimo.stanford.edu/sdr/metsrights/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mets="http://www.loc.gov/METS/">
    <mets:metsHdr ID="rennes1-ori-wf-1-19512" CREATEDATE="2024-05-29T14:37:58" LASTMODDATE="2024-05-29T14:37:58">
  <mets:agent ROLE="CREATOR">
            <mets:name>Université de Rennes</mets:name>
        </mets:agent>
</mets:metsHdr>
    <mets:dmdSec ID="desc_expr" CREATED="2024-05-29T14:37:58">
  <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_desc_these">
            <mets:xmlData>
                <tef:thesisRecord>
     <dc:title xml:lang="fr">Les vaccins à ARNm et leurs utilisations dans le cadre de la lutte contre les virus émergents</dc:title>
     <dcterms:alternative xml:lang="en">mRNA vaccines and their uses in the fight against emerging viruses</dcterms:alternative>
     <dc:subject xml:lang="fr">Vaccination</dc:subject><dc:subject xml:lang="fr">Vaccin</dc:subject><dc:subject xml:lang="fr">ARNm messager</dc:subject><dc:subject xml:lang="fr">ARNm</dc:subject><dc:subject xml:lang="fr">Virus émergent</dc:subject><dc:subject xml:lang="fr">Maladie émergente</dc:subject>
     <dc:subject xml:lang="en">Vaccination</dc:subject><dc:subject xml:lang="en">RNA messenger vaccine</dc:subject><dc:subject xml:lang="en">mRNA vaccine</dc:subject><dc:subject xml:lang="en">Emerging virus</dc:subject><dc:subject xml:lang="en">Emerging disease
</dc:subject><tef:sujetRameau><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="080840523">Maladies infectieuses émergentes‎</tef:elementdEntree>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="027314197">Virus‎</tef:elementdEntree>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="270447261">Vaccins à ARN messager</tef:elementdEntree>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="027255069">Vaccination</tef:elementdEntree>
					</tef:vedetteRameauNomCommun></tef:sujetRameau>
     <dcterms:abstract xml:lang="fr">Nous verrons à travers cette thèse par quels moyens la technique de vaccination par ARNm apporte  de grands changements par rapport aux anciennes générations de vaccins, quant à la rapidité de  développement, de production, des possibilités d'adaptations du vaccin et du faible risque des effets  secondaires tout en recherchant une réaction immunitaire efficace. Puis nous analyserons la place  des vaccins à ARNm dans la lutte contre les virus émergents. Nous finirons par analyser le rôle du  pharmacien dans la vaccination.</dcterms:abstract>
     <dcterms:abstract xml:lang="en">In this thesis, we will look at how the mRNA vaccination technique brings about major changes  compared with previous generations of vaccines, in terms of speed of development and production,  the possibility of adapting the vaccine and the low risk of side-effects, while at the same time seeking an effective immune response. We will then analyse the role of mRNA vaccines in the fight against emerging viruses. We will finish by analysing the role of the pharmacist in vaccination.</dcterms:abstract>
     <dc:type>Electronic Thesis or Dissertation</dc:type><dc:type xsi:type="dcterms:DCMIType">Text</dc:type>
     <dc:language xsi:type="dcterms:RFC3066">fr</dc:language>
    </tef:thesisRecord>
            </mets:xmlData>
        </mets:mdWrap>
</mets:dmdSec>
    <mets:dmdSec ID="desc_edition" CREATED="2024-05-29T14:37:58">
  <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_desc_edition">
            <mets:xmlData>
                <tef:edition><dcterms:medium xsi:type="dcterms:IMT">application/pdf</dcterms:medium><dcterms:extent>1 : 10373 Ko</dcterms:extent><dc:identifier xsi:type="dcterms:URI">https://ged.univ-rennes1.fr/nuxeo/site/esupversions/425fb171-2c26-4f29-a148-45f4f5eb343c</dc:identifier></tef:edition>
            </mets:xmlData>
        </mets:mdWrap>
</mets:dmdSec>
    <mets:amdSec>
        <mets:techMD ID="admin_expr">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_admin_these">
                <mets:xmlData>
                    <tef:thesisAdmin>
                        <tef:auteur>
       <tef:nom>Floch</tef:nom>
       <tef:prenom>Joan</tef:prenom>
       
       <tef:dateNaissance>1993-03-18</tef:dateNaissance>
       <tef:nationalite scheme="ISO-3166-1">FR</tef:nationalite>
       <tef:autoriteExterne autoriteSource="Sudoc">282936831</tef:autoriteExterne>
       <tef:autoriteExterne autoriteSource="mailPerso">joan.floch29@gmail.com</tef:autoriteExterne>
      </tef:auteur>
                        <dc:identifier xsi:type="tef:NNT">2024URENP030</dc:identifier>
                        <dc:identifier xsi:type="tef:nationalThesisPID">http://www.theses.fr/2024URENP030</dc:identifier>
                        <dcterms:dateAccepted xsi:type="dcterms:W3CDTF">2024-05-28</dcterms:dateAccepted>
                        <tef:thesis.degree>
                            <tef:thesis.degree.discipline xml:lang="fr">Pharmacie</tef:thesis.degree.discipline>
                            <tef:thesis.degree.grantor>
        <tef:nom>Universite de Rennes</tef:nom><tef:autoriteInterne>thesis.degree.grantor_1</tef:autoriteInterne>
        
        <tef:autoriteExterne autoriteSource="Sudoc">26693823X</tef:autoriteExterne>
       </tef:thesis.degree.grantor>
                            <tef:thesis.degree.level>Doctorat (thèse d'exercice)</tef:thesis.degree.level>
                        </tef:thesis.degree>
                        <tef:theseSurTravaux>non</tef:theseSurTravaux>
                        <tef:avisJury>oui</tef:avisJury><tef:directeurThese><tef:nom>Bousarghin</tef:nom><tef:prenom>Latifa</tef:prenom><tef:autoriteInterne>intervenant_1</tef:autoriteInterne><tef:autoriteExterne autoriteSource="Sudoc">076373347</tef:autoriteExterne></tef:directeurThese>
      
      
                        
                        <tef:oaiSetSpec>ddc:610</tef:oaiSetSpec>
                        
                    <tef:MADSAuthority authorityID="intervenant_1" type="personal"><tef:personMADS><mads:namePart type="family">Bousarghin</mads:namePart><mads:namePart type="given">Latifa</mads:namePart></tef:personMADS></tef:MADSAuthority><tef:MADSAuthority authorityID="thesis.degree.grantor_1" type="corporate"><tef:personMADS><mads:namePart>Universite de Rennes</mads:namePart><mads:description>Sciences et technologie, medecine, pharmacie, odontologie, droit, economie, gestion, philosophie</mads:description></tef:personMADS></tef:MADSAuthority></tef:thesisAdmin>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:techMD><mets:techMD ID="file_1"><mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_tech_fichier"><mets:xmlData><tef:meta_fichier>
     <tef:encodage>ASCII</tef:encodage>
     <tef:formatFichier>PDF</tef:formatFichier>
     
     
     
     <tef:taille>10622462</tef:taille>
    </tef:meta_fichier></mets:xmlData></mets:mdWrap></mets:techMD>
        
        <mets:rightsMD ID="dr_expr_thesard">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_auteur_these">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="true" DISPLAY="true" COPY="true" DUPLICATE="true" MODIFY="false" DELETE="false" PRINT="true"/>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
        <mets:rightsMD ID="dr_expr_univ">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_etablissement_these">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="true" DISPLAY="true" COPY="true" DUPLICATE="true" MODIFY="false" DELETE="false" PRINT="true"/>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
        <mets:rightsMD ID="dr_version">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_version">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="true" DISPLAY="true" COPY="true" DUPLICATE="true" MODIFY="false" DELETE="false" PRINT="true"/>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
    </mets:amdSec>
    <mets:fileSec>
  <mets:fileGrp ID="FGrID1" USE="archive"><mets:file ID="FID1" ADMID="file_1" MIMETYPE="application/pdf" USE="maitre"><mets:FLocat LOCTYPE="URL" xlink:href="https://ged.univ-rennes1.fr/nuxeo/site/esupversions/425fb171-2c26-4f29-a148-45f4f5eb343c"/></mets:file></mets:fileGrp>
 </mets:fileSec>
    <mets:structMap TYPE="logical">
        <mets:div DMDID="desc_expr" ADMID="dr_expr_thesard dr_expr_univ admin_expr" TYPE="THESE" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-19512/oeuvre">
            <mets:div ADMID="dr_version" TYPE="VERSION_COMPLETE" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-19512/oeuvre/version">
                <mets:div DMDID="desc_edition" TYPE="EDITION" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-19512/oeuvre/version/edition">
                    <mets:fptr FILEID="FGrID1"/>
                </mets:div>
            </mets:div>
        </mets:div>
    </mets:structMap>
</mets:mets>