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     <dc:title xml:lang="fr">Hydroxychloroquine, état des connaissances et implication dans la lutte contre le coronavirus SARS-CoV-2</dc:title>
     <dcterms:alternative xml:lang="en">Hydroxychloroquine, state of knowledge and implication in the fight against the SARS-CoV-2 coronavirus</dcterms:alternative>
     <dc:subject xml:lang="fr">Hydroxychloroquine</dc:subject><dc:subject xml:lang="fr">Pharmacocinétique</dc:subject><dc:subject xml:lang="fr">Pharmacologie</dc:subject><dc:subject xml:lang="fr">Effet antipaludéen</dc:subject><dc:subject xml:lang="fr">Effet immunitaire</dc:subject><dc:subject xml:lang="fr">Effet antiviral</dc:subject><dc:subject xml:lang="fr">SARS-CoV-2</dc:subject><dc:subject xml:lang="fr">Covid-19</dc:subject>
     <dc:subject xml:lang="en">Hydroxychloroquine</dc:subject><dc:subject xml:lang="en">Pharmacokinetics</dc:subject><dc:subject xml:lang="en">Pharmacology</dc:subject><dc:subject xml:lang="en">Antimalarial effect</dc:subject><dc:subject xml:lang="en">Immune effect</dc:subject><dc:subject xml:lang="en">Antiviral effect</dc:subject><dc:subject xml:lang="en">SARS-CoV-2</dc:subject><dc:subject xml:lang="en">Covid-19</dc:subject><tef:sujetRameau><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="243599358">SARS-CoV-2 (virus) </tef:elementdEntree>
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						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="24359934X">Covid-19</tef:elementdEntree>
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     <dcterms:abstract xml:lang="fr">L’hydroxychloroquine est une molécule connue depuis les années 1950. Historiquement utilisée en traitement préventif et curatif du paludisme, elle est actuellement indiquée dans le traitement de nombreuses pathologies rhumatismales. En 2019, un virus parti de Chine s’est rapidement propagé sur tous les continents donnant naissance à une pandémie. Lors de cette pandémie l’hydroxychloroquine va rencontrer un engouement très controversé. L’objectif est de voir comment une molécule, qui à priori ne semble pas avoir d’indication dans des pathologies virales, va se retrouver au coeur d’une polémique mondiale concernant son utilisation contre ce virus, le SARS-CoV-2.</dcterms:abstract>
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