<?xml version="1.0" encoding="UTF-8"?><mets:mets xmlns:mads="http://www.loc.gov/mads/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:tef="http://www.abes.fr/abes/documents/tef" xmlns:metsRights="http://cosimo.stanford.edu/sdr/metsrights/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mets="http://www.loc.gov/METS/">
    <mets:metsHdr ID="rennes1-ori-wf-1-15570" CREATEDATE="2021-09-28T19:00:22" LASTMODDATE="2021-09-28T19:00:22">
  <mets:agent ROLE="CREATOR">
            <mets:name>Université de Rennes 1</mets:name>
        </mets:agent>
</mets:metsHdr>
    <mets:dmdSec ID="desc_expr" CREATED="2021-09-28T19:00:22">
  <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_desc_these">
            <mets:xmlData>
                <tef:thesisRecord>
     <dc:title xml:lang="en">Acquired agitation in critically ill patients with COVID-19 compared to influenza patients: are the pictures different ?</dc:title>
     <dcterms:alternative xml:lang="fr">Comparaison de l'agitation acquise en réanimation chez les patients COVID-19 par rapport aux patients atteints de grippe : des tableaux différents?</dcterms:alternative>
     <dc:subject xml:lang="fr">Covid-19</dc:subject><dc:subject xml:lang="fr">grippe</dc:subject><dc:subject xml:lang="fr">réanimation</dc:subject><dc:subject xml:lang="fr">agitation</dc:subject><dc:subject xml:lang="fr">délirium</dc:subject><dc:subject xml:lang="fr">encéphalopathie</dc:subject>
     <dc:subject xml:lang="en">Covid-19</dc:subject><dc:subject xml:lang="en">influenza</dc:subject><dc:subject xml:lang="en">ICU</dc:subject><dc:subject xml:lang="en">agitation</dc:subject><dc:subject xml:lang="en">delirium</dc:subject><dc:subject xml:lang="en">encephalopathy</dc:subject><tef:sujetRameau><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="243599358">SARS-CoV-2 (virus)</tef:elementdEntree>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="24359934X">Covid-19</tef:elementdEntree>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="027457850">Grippe</tef:elementdEntree>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="050514873">Agitation psychomotrice</tef:elementdEntree>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="027453987">Réanimation</tef:elementdEntree><tef:subdivision autoriteSource="Sudoc" type="subdivisionDeSujet" autoriteExterne="027790967">Complications (médecine)</tef:subdivision>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="027504239">Encéphalopathies</tef:elementdEntree>
					</tef:vedetteRameauNomCommun><tef:vedetteRameauNomCommun>
						<tef:elementdEntree autoriteSource="Sudoc" autoriteExterne="027803503">Études comparatives</tef:elementdEntree>
					</tef:vedetteRameauNomCommun></tef:sujetRameau>
     <dcterms:abstract xml:lang="fr">Parmi les présentations cliniques d’une atteinte à SARS-CoV-2, il existe des manifestations neurologiques à type de céphalées, de confusion, voire d’encéphalopathie. Des études avaient déjà rapporté un taux plus important de manifestations neurologiques chez les patients de réanimation. Nous avons mené une étude rétrospective visant à déterminer l’incidence de l’agitation chez les patients atteints de SARS CoV-2 admis en réanimation au CHU de Rennes et requérant une ventilation mécanique, en comparaison à une population de patients atteints de grippe. Nous avons inclus 146 patients Covid-19 et 94 patients atteints de grippe. Nous avons mis en évidence un taux significativement plus important d’agitation chez les patients Covid-19 (54.8 % vs 33.0%, p value &lt; 0.001). Après un appariement selon un score de propension, l’agitation reste significativement plus élevée chez les patients Covid-19. L’agitation est associée indépendamment à la mortalité après ajustement avec les autres facteurs (HR = 1.85, 95% CI 1.37-2.49, p &lt; 0.001).</dcterms:abstract>
     <dcterms:abstract xml:lang="en">Among clinical features of SARS-CoV-2 infection, neurological manifestations have been described, such as headache, confusion, or encephalopathy. Several studies had already reported a higher rate of neurological manifestations in the critically ill patients. We conducted a retrospective study to assess the incidence of agitation among patients with SARS-CoV-2 infection admitted in ICU in Rennes University Hospital and requiring mechanical ventilation, in comparison with a population of patients with influenza. We included 146 patients with Covid-19 and 94 patients with influenza. We showed a significantly higher rate of agitation in patients with Covid-19 (54.8% vs 33.0%, p value &lt; 0.01). After propensity score matching, agitation remained significantly higher in Covid-19 patients. Agitation was independently associated with mortality after adjustment for other factors (HR = 1.85, 95% CI 1.37-2.49, p &lt; 0.001).</dcterms:abstract>
     <dc:type>Electronic Thesis or Dissertation</dc:type><dc:type xsi:type="dcterms:DCMIType">Text</dc:type>
     <dc:language xsi:type="dcterms:RFC3066">en</dc:language>
    </tef:thesisRecord>
            </mets:xmlData>
        </mets:mdWrap>
</mets:dmdSec>
    <mets:dmdSec ID="desc_edition" CREATED="2021-09-28T19:00:22">
  <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_desc_edition">
            <mets:xmlData>
                <tef:edition><dcterms:medium xsi:type="dcterms:IMT">application/pdf</dcterms:medium><dcterms:extent>1 : 507 Ko</dcterms:extent><dc:identifier xsi:type="dcterms:URI">https://ged.univ-rennes1.fr/nuxeo/site/esupversions/2a06ea01-5a15-4df3-8aba-4cc3d5519515</dc:identifier></tef:edition>
            </mets:xmlData>
        </mets:mdWrap>
</mets:dmdSec>
    <mets:amdSec>
        <mets:techMD ID="admin_expr" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_admin_these">
                <mets:xmlData>
                    <tef:thesisAdmin>
                        <tef:auteur>
       <tef:nom>Liard</tef:nom>
       <tef:prenom>Clémence</tef:prenom>
       
       <tef:dateNaissance>1993-12-14</tef:dateNaissance>
       <tef:nationalite scheme="ISO-3166-1">FR</tef:nationalite>
       <tef:autoriteExterne autoriteSource="Sudoc">260788317</tef:autoriteExterne>
       <tef:autoriteExterne autoriteSource="mailPerso">liard.clemence@gmail.com</tef:autoriteExterne>
      </tef:auteur>
                        <dc:identifier xsi:type="tef:NNT">2021REN1M162</dc:identifier>
                        <dc:identifier xsi:type="tef:nationalThesisPID">http://www.theses.fr/2021REN1M162</dc:identifier>
                        <dcterms:dateAccepted xsi:type="dcterms:W3CDTF">2021-10-06</dcterms:dateAccepted>
                        <tef:thesis.degree>
                            <tef:thesis.degree.discipline xml:lang="fr">MEDECINE</tef:thesis.degree.discipline>
                            <tef:thesis.degree.grantor>
        <tef:nom>Universite de Rennes 1</tef:nom><tef:autoriteInterne>thesis.degree.grantor_1</tef:autoriteInterne>
        
        <tef:autoriteExterne autoriteSource="Sudoc">02778715X</tef:autoriteExterne>
       </tef:thesis.degree.grantor>
                            <tef:thesis.degree.level>Doctorat (thèse d'exercice)</tef:thesis.degree.level>
                        </tef:thesis.degree>
                        <tef:theseSurTravaux>non</tef:theseSurTravaux>
                        <tef:avisJury>oui</tef:avisJury><tef:directeurThese><tef:nom>Maamar</tef:nom><tef:prenom>Adel</tef:prenom><tef:autoriteInterne>intervenant_1</tef:autoriteInterne><tef:autoriteExterne autoriteSource="Sudoc">191542326</tef:autoriteExterne></tef:directeurThese>
      
      
                        
                        
                        <tef:oaiSetSpec>ddc:610</tef:oaiSetSpec>
                        
                        
                    <tef:MADSAuthority authorityID="intervenant_1" type="personal"><tef:personMADS><mads:namePart type="family">Maamar</mads:namePart><mads:namePart type="given">Adel</mads:namePart></tef:personMADS></tef:MADSAuthority><tef:MADSAuthority authorityID="thesis.degree.grantor_1" type="corporate"><tef:personMADS><mads:namePart>Universite de Rennes 1</mads:namePart><mads:description>Sciences et technologie, medecine, pharmacie, odontologie, droit, economie, gestion, philosophie</mads:description></tef:personMADS></tef:MADSAuthority></tef:thesisAdmin>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:techMD><mets:techMD ID="file_1"><mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_tech_fichier"><mets:xmlData><tef:meta_fichier>
     <tef:encodage>ASCII</tef:encodage>
     <tef:formatFichier>PDF</tef:formatFichier>
     
     
     
     <tef:taille>519002</tef:taille>
    </tef:meta_fichier></mets:xmlData></mets:mdWrap></mets:techMD>
        
        <mets:rightsMD ID="dr_expr_thesard" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_auteur_these">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="true" DISPLAY="true" COPY="true" DUPLICATE="true" MODIFY="false" DELETE="false" PRINT="true"/>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
        <mets:rightsMD ID="dr_expr_univ" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_etablissement_these">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="false" DISPLAY="false" COPY="false" DUPLICATE="false" MODIFY="false" DELETE="false" PRINT="false"/>
       <metsRights:Constraints CONSTRAINTTYPE="TIME" OTHERCONSTRAINTTYPE="">
								
        <metsRights:ConstraintDescription>confidentialité 2021-10-06 2022-06-30</metsRights:ConstraintDescription>
							</metsRights:Constraints>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
        <mets:rightsMD ID="dr_version" CREATED="">
            <mets:mdWrap MDTYPE="OTHER" OTHERMDTYPE="tef_droits_version">
                <mets:xmlData>
                    <metsRights:RightsDeclarationMD>
                        <metsRights:Context CONTEXTCLASS="GENERAL PUBLIC">
                            <metsRights:Permissions DISCOVER="false" DISPLAY="false" COPY="false" DUPLICATE="false" MODIFY="false" DELETE="false" PRINT="false"/><metsRights:Constraints CONSTRAINTTYPE="TIME">
								<metsRights:ConstraintDescription>restriction 2021-10-06 2022-06-30</metsRights:ConstraintDescription>
							</metsRights:Constraints>
                        </metsRights:Context>
                    </metsRights:RightsDeclarationMD>
                </mets:xmlData>
            </mets:mdWrap>
        </mets:rightsMD>
    </mets:amdSec>
    <mets:fileSec>
  <mets:fileGrp ID="FGrID1" USE="archive"><mets:file ID="FID1" ADMID="file_1" MIMETYPE="application/pdf" USE="maitre"><mets:FLocat LOCTYPE="URL" xlink:href="https://ged.univ-rennes1.fr/nuxeo/site/esupversions/2a06ea01-5a15-4df3-8aba-4cc3d5519515"/></mets:file></mets:fileGrp>
 </mets:fileSec>
    <mets:structMap TYPE="logical">
        <mets:div DMDID="desc_expr" ADMID="dr_expr_thesard dr_expr_univ admin_expr" TYPE="THESE" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-15570/oeuvre">
            <mets:div ADMID="dr_version" TYPE="VERSION_COMPLETE" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-15570/oeuvre/version">
                <mets:div DMDID="desc_edition" TYPE="EDITION" CONTENTIDS="http://ori-oai-search.univ-rennes1.fr/uid/rennes1-ori-wf-1-15570/oeuvre/version/edition">
                    <mets:fptr FILEID="FGrID1"/>
                </mets:div>
            </mets:div>
        </mets:div>
    </mets:structMap>
</mets:mets>